The primary purpose of this application is to continue and enhance development of the Mayo Clinic Comprehensive Cancer Center in a manner that will: 1. Increase the number and scope of our basic cancer research programs and to facilitate meaningful communication and interaction between these programs and our clinical research efforts. 2. Facilitate and expand clinical cancer research programs. 3. Continue the development of programs of cancer education and demonstration involving medical students, graduate students, our own staff and the regional physician as well as those working in cancer nursing, social services, rehabilitation, epidemiology, and cancer statistics. 4. Foster and enhance multidisciplinary programs in cancer diagnosis and management and to make these programs productive sources of clinical research and education. 5. Continue and expand our efforts to develop and evaluate cost effective methods of cancer detection and screening. 6. Continue efforts to strengthen statistical support for our research programs, our community and regional programs, and our programs of cancer rehabilitation and control. 7. Expand current programs of meaningful service to the physician and cancer patient of our community. 8. Contribute to cancer control in our region through the vehicles of improved communication, fostering the development of state cancer councils and inauguration of the North Central Cancer Treatment Group.